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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
19.09
Human Site:
S315
Identified Species:
35
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
S315
K
N
P
A
E
R
M
S
Y
L
E
L
M
E
H
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
D351
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
S315
K
N
P
A
E
R
M
S
Y
L
E
L
M
E
H
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
S315
K
N
P
A
E
R
M
S
Y
L
E
L
M
E
H
Rat
Rattus norvegicus
Q4KSH7
419
47517
P369
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S320
K
N
P
A
E
R
M
S
Y
L
E
L
M
E
H
Chicken
Gallus gallus
Q90891
398
44059
D357
K
N
P
A
E
R
A
D
L
K
M
L
M
N
H
Frog
Xenopus laevis
Q07192
446
50082
K401
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
E328
C
L
R
K
N
S
T
E
R
P
T
Y
T
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
K303
P
N
Y
E
Q
L
L
K
H
S
F
I
V
E
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
P319
T
K
D
R
R
H
R
P
K
Y
D
T
L
K
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
S321
K
D
P
P
A
R
A
S
S
L
D
L
L
S
H
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
T613
K
I
P
E
R
R
P
T
Y
A
A
L
T
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
60
N.A.
100
N.A.
100
0
N.A.
100
60
6.6
6.6
N.A.
20
N.A.
0
N.A.
P-Site Similarity:
100
66.6
N.A.
100
N.A.
100
13.3
N.A.
100
60
20
6.6
N.A.
53.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
47
8
0
24
0
0
8
8
0
0
0
0
% A
% Cys:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
16
0
8
0
0
16
0
0
16
0
0
0
0
% D
% Glu:
0
0
0
16
47
8
0
8
0
0
31
0
0
62
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
8
0
8
0
0
8
0
0
0
0
0
70
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
62
16
0
16
0
8
0
16
16
16
8
8
8
8
0
% K
% Leu:
0
16
0
0
0
8
8
0
16
39
0
62
24
8
16
% L
% Met:
0
0
0
0
0
0
31
0
0
0
8
0
47
0
0
% M
% Asn:
0
54
0
0
8
0
0
0
0
0
8
0
0
8
0
% N
% Pro:
8
0
62
8
0
0
8
16
0
16
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
8
8
24
62
16
0
16
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
8
39
8
8
0
0
0
8
8
% S
% Thr:
16
0
8
0
0
0
8
8
0
0
8
8
16
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
39
16
0
16
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _